Virology Why is it so hard to get a vaccine against hepatitis C?

Most vaccines work by inducing the production of antibodies that target the outer surfaces of viruses. However, hepatitis C viruses of different strains differ greatly from each other and mutate rapidly, which complicates the creation of an effective vaccine

A new method of creating a vaccine was developed by a former graduate student and currently a doctoral student of the Experimental Group of Virologists (Experimental Virology group) By Peter J. Canvas (Peter J. Holst). The research team also included Professor Thomson and Associate Professor Jan Pravsgaard Christensen.

"The cells of the immune system move with the blood flow and monitor the condition of other cells by scanning their surface proteins. If foreign proteins and other biomolecules are found in the body, the protection mechanism is activated. But the defenses given to man by nature do not detect the virus until it has penetrated into the cells and started its destructive work," says Professor Thomsen

The new vaccine stimulates and accelerates the immune system. The vaccine works by presenting immune cells with the most stable, internally conserved virus molecules, which, unlike surface viral molecules, mutate at a slower rate.
After vaccination with a new vaccine, the cells of the body present the cells of the immune system with sections of the surface and internal molecules of the virus. As a result, a very powerful immune response develops, one of the components of which is the activation of special cells - natural killers that destroy cells infected with the virus.

@ekaterina-gribacheva Is it about the development of a new hepatitis C vaccine?

@antony10 Could we use then some mixture of antibodies?)

@ekaterina-gribacheva Bad in the end) I hope that there will be some solution, which is able to start working before the destruction occurs.

@ekaterina-gribacheva How do we measure the stability of viruses inside the vaccine?

@ekaterina-gribacheva Btw do you have a link to the paper?

@morphism Sounds reasonable, but Peter J. Holst's research is already yielding results)

@argentum yes, this research is very promising)

@morphism       
this link will talk about vaccine stability and other factors)

https://link.springer.com/article/10.1208/s12249-018-1254-2

@ekaterina-gribacheva Ok, I will check it

@antony10 yeah, let's see it on a longer time frame