Radiopharmaceuticals radiomodifying agents
Hi everyone! I've read today about radiomodifying agents - factors that can change radiosensitivity of cells, tissues and the body. I don't fully understand the mechanism of the action of such substances. Can anybody explain? Maybe someone knows any examples?
Hard to answer! Maybe these compounds can reveal the answer: Resveratrol and Bilirubin. These substances are used as radiomodifying agents.
@morphism that's interesting! I've heard only about antioxidant properties of Resveratrol
Good evening! Radioprotective compounds include some vitamins, for example, groups B and C. Vitamins B1, B3, B6, B12 improve the regeneration of hematopoiesis, accelerate the recovery of erythrocytes and leukocytes. Ascorbic acid doesn't have a protective effect, but enhances the effect of vitamins B and P. If radiation reduces blood clotting, then vitamins P and K1 normalize the prothrombin index. Also, as far as I know, p-aminobenzoic acid increases the body's resistance to the development of radiation sickness
I've also read somewhere that phenolic compounds of plants are considered as promising sources of active antiradiation agents, because they increase the strength of blood vessels and regulate the functioning of the endocrine glands
@elizaveta-msu I'm not a specialist in the field) Just heard that the compound could be useful
@_brauer_ Do I understand correctly that problems with hematopoiesis are one of the most serious consequences of radiation exposure for humans?
@elizaveta-msu it's really interesting to find here the Bilirubin, because it's kind of very specific compound...
@morphism what do you mean? actually I'm not very good in biochemistry and physiology
@elizaveta-msu The Bilirubin participates in the body's clearance of waste products that arise from the destruction of aged or abnormal red blood cells. And this well-known substance works like radiomodifying agent! How could imagine that?)
@morphism I think, this is due to the fact that radiation exposure significantly damages the hematopoietic system, and bilirubin, if I understand correctly, is connected with the processes occurring in the blood
@elizaveta-msu I think yes - problems with hematopoiesis are one of the most serious consequences of radiation exposure for humans. In particular, human bone marrow is highly sensitive to radiation.
I do not fully understand by the radio-modifying agent, you mean things that preserve or increase the sensitivity to radiation?
@argentum radiomodification - weakening or strengthening the reactions of biological objects to the action of ionizing radiation. Specifically in this thread we discussed radioprotectors - substances that weaken the sensitivity of cells and tissues to radiation