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Topic starter 05/02/2022 1:30 pm
Hello) The pharmacological efficacy and safety of many drugs today can be predicted by determining the personal phenotype of the metabolizing system. How exactly is the phenotype of the metabolizing system determined?
06/02/2022 3:37 pm
Hello) The pharmacological efficacy and safety of many drugs today can be predicted by determining the personal phenotype of the metabolizing system. How exactly is the phenotype of the metabolizing system determined?
Genetic polymorphism makes it possible to divide people taking medications (metabolizers) into 3 groups according to their phenotype: extensive, slow and fast.
An allele with genes encoding enzyme production is homozygous and unchanged.
Slow metabolizers are characterized by a reduced rate of drug metabolism. In representatives of this type, the intensity of synthesis of the enzyme that metabolizes LP may decrease and / or its inactive (inactive) form may be produced. The change in the function of the enzyme is due to the polymorphism of the allelic gene encoding its synthesis. Failure of enzymatic stimulation causes the accumulation of drugs as a stimulus, which often leads to severe side effects.
Rapid metabolizers are individuals with an increased metabolic rate for a particular drug. A feature of their genome is the presence of a "fast genetic enzyme"; individuals with copies of alleles that are the result of genetic polymorphism are often found. As a result, the metabolic rate of the drugs increases in these individuals.
In order to optimize pharmacotherapy, it is necessary to conduct a genetic study aimed at identifying enzyme polymorphism. An effective method of genotyping can be the use of the polymerase chain reaction method.