Pharmacology What is the mechanism of action of PCSK9 inhibitors?

A number of PCSK9 categories are currently being developed.
The main categories are:

1) monoclonal antibodies and peptides that bind directly to PCSK9, preventing PCSK9 from binding to low-density lipoprotein (LDL) receptors; 

2) gene silencing that reduces the production of PCSK9.
Simply put, the main strategies are to block PCSK9 or reduce it.

@ekaterina-gribacheva what's the purpose of PCSK9 inhibition?

I join the question, why do all this?

@morphism @argentum PCSK9 inhibitors are used for primary and secondary prevention, are prescribed to patients with familial forms of dyslipidemia, with statin intolerance, with acute coronary syndrome, with elevated levels of hyperLp (a), patients with diabetes mellitus. Thus, PCSK9 inhibitors are effective in various groups of patients, including high, very high and extreme risk.

@ekaterina-gribacheva Do you what are the molecular features, which make PCSK9 inhibitors so efficient?

@ekaterina-gribacheva And as a result, they increase life expectancy?

@argentum In my opinion - yes