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Pharmacology How to increase selectivity in drugs?

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morphism
 morphism
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Topic starter 03/02/2022 8:41 pm  

Hello, everyone! Does anybody know about the ways how to increase drugs' selectivity?


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drugs drug design
Argentum
 Argentum
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04/02/2022 4:16 pm  

Hello! As far as I know, selectivity depends directly on their chemical structure, which determines the physicochemical properties and interaction with receptors.


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morphism
 morphism
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Topic starter 05/02/2022 12:45 pm  

@argentum you mean e.g. different conformations?


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Argentum
 Argentum
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05/02/2022 11:58 pm  

@morphism No, I meant a different chemical structure


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morphism
 morphism
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Topic starter 06/02/2022 7:21 pm  

@argentum could you imagine different isomers with different properties? Why is it so?


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Argentum
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06/02/2022 8:21 pm  

@morphism Yes, there are many such examples, with monosaccharides, amino acids. This is due to the fact that enzymes also have stereoisomers and react only with certain isomeric substrates due to their high specificity.


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morphism
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Topic starter 20/02/2022 11:46 am  

@argentum ok, I got it, thanks!


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Argentum
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20/02/2022 5:24 pm  

You are wellcome!


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morphism
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Topic starter 07/05/2022 9:25 am  

@argentum 😉 


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