Pharmacology Clinical pharmacology of tranquilizers

What exactly interests you in it?

@argentum Good afternoon, I am interested in the mechanism of action)

@ekaterina-gribacheva The mechanisms of action of tranquilizers are still not well understood. Neurophysiological studies indicate a decrease under the influence of tranquilizers in the excitability of the subcortical areas of the brain (limbic system, thalamus, hypothalamus), which are responsible for the implementation of emotional reactions and inhibition of the interaction between these structures and the cerebral cortex. In the neurochemical aspect, different tranquilizers differ in the specifics of their action. The effect on the noradrenergic, dopaminergic and serotonergic systems is expressed in them to a relatively weak degree. At the same time, benzodiazepine tranquilizers actively affect the GABAergic systems, potentiating the central inhibitory effect of gamma-aminobutyric acid. In the cells of the central nervous system, specific benzodiazepine receptors (and their subgroups) were found, for which benzodiazepines are exogenous ligands. The nature of the endogenous ligand for these receptors has not been completely elucidated. There is a close relationship between benzodiazepine receptors and GABA receptors.

@argentum Simply speaking - it works like emotions suppressor? 

@morphism in particular yes

@argentum long use can cause emotional dumbness?

@morphism I can't really say for sure

@argentum Ok, I think that there's some connection...

@morphism maybe

@argentum 🤔