Organometallics What is the product?
Ortofluorophenyl magnesium bromide
@nanoserebro I do not think so.
The magnesium is there to create benzyne in-situ. And reactive benzyne with furan reacts in 4+2 Diels-Alder fashion and gives the product depicted in the picture.
@argentum Do you mean that it is possible to avoid the 1,2-Elimination? Have you found some references in papers about that?
@igorgordiy I think on the basis of logic and considerations, they should be formed in between?
@nanoserebro Sure, but it could be very problematic to isolate them in the experiment...
I guess the elimination is really fast in this case and it is 100% very good favored by enthalpy and also entropy
How to run this cycloaddition enantioselectively?
@yln Do you think that this product is optically active?)
Or do you ask about the more general case?
@yln You would probably be interested in this paper: https://onlinelibrary.wiley.com/doi/10.1002/adsc.200600319
Here the enantioselective cycloadditions of arynes are discussed, and the the reaction of this topic should be considered as the cycloaddition of the in-situ generated aryne 😉