Physical organic chemistry Protective group for OH
Topic starter 29/12/2021 6:37 pm
Hi. What is the most commonly used protective group used for alcohols and why is it so popular? I've got lost in all different varieties and want to detect basic one
30/12/2021 8:17 pm
I ordinary use benzyl protective group, because its easy to protect and to remove under H2 + Pd/C.
Also commonly use t-butyl, allyl, Tetrahydropyranyl either protection groups.
31/12/2021 8:43 pm
quite often TBDMS (tert-butyldimethylsilyl) and MOM (methoxymethyl) are also used
Elizaveta MSU liked
28/02/2022 11:49 pm
Also Boc is a abundant one