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Topic starter 15/04/2022 10:13 pm
Why PCl5 is used for synthesis thesis of RCl from ROH? Same reaction for RBr proceeds with HBr just fine
15/04/2022 10:28 pm
Alcohols also react with HCl, only under more severe conditions, due to the fact that the chloride anion is a weaker nucleophile than bromide.
Topic starter 16/04/2022 9:14 pm
@argentum Thank you! As far as I remember, phosphorous plays the main role in the mechanism, but I don't not what is so unique about it
16/04/2022 11:31 pm
@chaoticgood It plays the role of a Lewis acid, coordinating with the oxygen atom, turning it into a "good" leaving group
19/07/2022 10:17 pm
PCl5 isn't a good choise for alkyl chloride synthesis due to its price and purify. Also the remaining POCl3 is a nightmare of next water treatement or distillation. It is much better to use thionyl chloride or dry HCl/ZnCl2 IMHO