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Topic starter 01/01/2022 6:46 pm
Hi guys. I've heard that DMF have some kind of negative aura around it: chemists are trying to avoid it in their synthesis. Why is it so? In my opinion it's properties are quite unique
03/01/2022 7:45 pm
Hey! Based on personal experience, I can say that DMF is quite difficult to evaporate and it is difficult to separate from the products during extraction.
Topic starter 14/01/2022 7:46 pm
Also it is quite toxic and cannot be used in medicinal synthesis
15/01/2022 6:36 pm
@elizaveta-msu if you need to work with DMF you can add toluene to it, they form an azeotropic mixture, then there will be no such difficulties with evaporation
23/06/2022 6:31 am
DMF doesn't like to pull into CCl4 (not CHCl3 or CH2Cl2) so you can use it for extractions. The bp is relatively high, but vacuum distillation does its job and I think about 55°C on water-jacked pump is acceptable for most purposes
Marie Curie liked
10/07/2022 4:12 pm
@chemdimon I knew only about toluene, not about CCl4, thanks for the information!