Immunology Oncolytic viruses
Why are oncolytic viruses not being destroyed by our immune system?
Hello! Because often the oncolytic viruses go into the body with immunosuppression based on chemotherapy! Also, oncolytic viruses are designed in a specific way. The way with a goal to be like not common human pathogens. In result, a human' immune system cannot produce antibodies.
The immune system only reacts to the invasive virus after the cells begin to die. The signals released by dying cells cause the immune system to dramatically increase its response, far beyond the resting level. The idea behind the oncolytic virus is to enter the tumor as quickly as possible so that it can do its job right away. By the time the immune system begins to destroy the virus, it has already done what it was designed to do.
I understood, thanks)
What viruses are used to fight tumors?
@argentum adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus.
@morphism I wonder if this is already being used in clinical practice, or is it just experiments yet?