Drug discovery Why lipophilicity is so important in Drug Design?
Hello, everyone! Do you have any idea why lipophilicity is so important in drug design process?
I can’t say for sure, this is probably due to the need to pass through membrane lipids
Lipophilicity is a primary underlying structural property that affects higher-level physicochemical and biochemical properties. Lipophilicity values are usually measured for drug candidates to support structure-activity relationships, absorption and tissue distribution prediction, physiologically based pharmacokinetic modeling, preformulation, formulation, and environmental assessment.
However, there are also hydrophilic drugs
@morphism e.g. water soluble vitamins, amino acids, drug injections often also in aqueous solution