Drug discovery Prodrugs: what is it?
Hello, everyone! Do you know anything about prodrugs? Any examples? Are they nothing special until they cross a liver?
As far as I know, they are used for the targeted delivery of drugs to the necessary organs, tissues, etc, aren't they?
@elizaveta-msu yep, they are but do you know the exact prodrugs' behavior?
@morphism A prodrug is a medication or compound that, after administration, is metabolized into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted. Prodrugs can be classified into two major types, based on how the body converts the prodrug into the final active drug form:
Type I prodrugs are bioactivated inside the cells (intracellularly). Examples of these are anti-viral nucleoside analogs that must be phosphorylated and the lipid-lowering statins.
Type II prodrugs are bioactivated outside cells (extracellularly), especially in digestive fluids or in the body's circulatory system, particularly in the blood. Examples of Type II prodrugs are salicin and certain antibody-, gene- or virus-directed enzyme prodrugs used in chemotherapy or immunotherapy