Hi) Responsive design can improve trial performance for the sponsor and study participants. However, if such studies are not performed correctly, there is a high risk of obtaining clinical results that will be difficult to interpret or implement in everyday practice.
@marie-curie Adaptive(Responsive) clinical trial designs are relatively flexible designs that allow changes to be made during a trial to speed up and streamline the process. The analyzes of the data collected in the study are carried out at pre-planned time points within the trial; they can be carried out in a completely blind mode or openly with optional formal testing of a statistical hypothesis. It is important that the process is modified in such a way that the validity and integrity of the test is maintained.
Also, you can use computational methods to speed up the research!)