Drug discovery Biotechnological (biological) products
Can you talk about testing methods and acceptance criteria for biotechnological (biological) products?
Why do you mean? E.g. we have result of a Asymmetric catalysis, what's next? Do you want to quantify results?
@morphism I am interested in what methods we use to test products that we would like to use in preparations? And by what criteria should we evaluate them?
@benzol00 we could use any methods, which can assess ADME properties e.g. - absorption, distribution, metabolism and elimination. Are you interested in this?
@morphism Yes, I really want to know the preparation process for further preparation of drugs)
@benzol00 E.g. pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. This is a very important step, where as a researcher you have to take into account how a drug will be processed in body. Through stomach or through intestines
@benzol00 Formulations are a very important aspect of creating medicines, since they are essential to ensuring that the active part of the drug is delivered to the correct part of the body, in the right concentration, and at the right rate (not too fast and not too slowly). A good example is a drug delivery system that exploits supersaturation. They also need to have an acceptable taste (in the case of pills, tablets or syrups), last long enough in storage still to be safe and effective when used, and be sufficiently stable both physically and chemically to be transported from where they are manufactured to the eventual consumer. Competently designed formulations for particular applications are safer, more effective, and more economical than any of their components used singly.
Effective modeling and optimization methods are needed to develop an optimal system of formulations.
So in pharmaceuticals, the formulation affects both the physico-chemical properties and the bioavailability of drugs.
Thanks everyone for the replies